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Domain I (random sequence generation)
Domain II (allocation concealment)
Domain III + a (blinding of participants and personnel)
Domain IV + a (blinding of outcome assessors)
Reviews included (from original 729 reviews)
Surgical studies N (% of included)
77 (10.9%)
79 (10.7%)
72 (10.5%)
79 (11.0%)
Non-surgical studies N (% of included)
652 (92.0%)
659 (89.3%)
613 (89.5%)
642 (89.0%)
Total N (%)
709 (97.3%)
717 (98.4%)
685 (94.0%)
721 (98.9%)
Studies with domain missing (from original 10,537 studies)
Surgical N (%)
37 (0.4%)
28 (0.3%)
54 (0.5%)
16 (0.2%)
Non-surgical N (%)
402 (3.8%)
329 (3.1%)
752 (7.1%)
417 (4.0%)
Overall N (%)
439 (4.2%)
357 (3.4%)
806 (7.6%)
433 (4.1%)
Studies observed (from original 10,537 studies)
Surgical N (%)
778 (7.4%)
789 (7.5%)
761 (7.2%)
808 (7.7%)
Non-surgical N (%)
9320 (88.5%)
9391 (89.1%)
8970 (85.1%)
9296 (88.2%)
Overall N (%)
10,098 (95.8%)
10,180 (96.6%)
9731 (92.4%)
10,104 (95.9%)
Judgments analyzed (from number of observed studies in domain)
Surgical N (%)
778 (7.7%)
789 (7.7%)
945 (8.4%)
924 (7.8%)
Non-surgical N (%)
9325 (92.3%)
9459 (92.3%)
10,266 (91.6%)
10,957 (92.2%)
Surgical + N (+%) b
0 (+ 0.0%)
0 (+ 0.0%)
184 (+ 19.5%)
116 (+ 12.6%)
Non-surgical + N (+%) b
5 (+ 0.1%)
68 (+ 0.7%)
1296 (+ 12.6%)
1661 (+ 15.2%)
Overall N (+%) b
10,103 (+ 0.0%)
10,248 (+ 0.7%)
11,211 (+ 13.2%)
11,881 (+ 15.0%)
a Also includes data for joint domain of blinding of participants, personnel, and outcome assessorb Cochrane authors provided additional multiple judgments (for different outcomes)
